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This 25 minutes video explains intimately the mechanisms of motion for mRNA COVID-19 vaccines, in addition to highlighting a number of the recognized dangers. If you need a greater understanding of the know-how or want for a refresher on the tech, in addition to to study a little bit of mobile and molecular biology – this can be a nice primer. So, sit again, loosen up and open your thoughts to a little bit of science.
Evaluation of the Peer Reviewed Research
Neutralizing Antibodies Towards the SARS-CoV-2 Omicron Variant (BA.1) 1 to 18 Weeks After the Second and Third Doses of the BNT162b2 mRNA Vaccine. JAMA Netw Open. 2022;5(5):e2212073. doi:10.1001/jamanetworkopen.2022.12073
The summary of the paper first mentions that in early medical trials, SARS-CoV-2 neutralizing antibodies have been correlated with safety towards an infection and illness brought on by early viral variants, however not talked about by the authors – this correlation has not been demonstrated with the varied Omicron variants.
The authors of this present work, which focuses on the Pfizer/BioNTech vaccine, observe that in research carried out by Moderna, there’s an noticed lower in neutralizing antibody titers within the vaccinated inhabitants which corresponds to a lower in vaccine efficacy towards polymerase chain response – confirmed Omicron an infection in Denmark and symptomatic Omicron an infection in the UK.
The research has a curious choice bias – it solely consists of males, and it neither captures nor analyzes any knowledge regarding efficacy or effectiveness endpoints.
This research repeatedly asserts that there’s a demonstrated correlation between neutralizing antibody titers and safety towards an infection and illness, however depends on historic knowledge from non-Omicron variants to help this declare.
- This research detected a fast decline in Omicron-specific serum neutralizing antibody titers only some weeks after the second and third doses of BNT162b2.
- For these aged 65 and older, there have been virtually no Omicron-specific serum neutralizing antibody titers after dose 2 (see Determine 2, panel B).
- For these aged 65 and older, there have been virtually no Omicron-specific serum neutralizing antibody titers by week 8 after dose 3.
Please assessment Determine 2, which clearly exhibits these outcomes:
Taken collectively, this work clearly demonstrates that vaccine-induced protecting antibody responses following a second and third dose of BNT162b2 are each very low and transient in older folks (which is the cohort at most vital danger of hospitalization and demise).
The article mentions that conserved T-cell immunity and non-neutralizing antibodies should present safety towards hospitalization and demise whilst neutralizing antibodies wane, however the research didn’t truly measure T-cell immunity and non-neutralizing antibodies.
The authors conclude that “further booster doses could also be obligatory, significantly in older folks.” Following their logic, one can view the above desk and observe that the ranges of safety quickly wanes after week 4 in these older than 65 years after dose 3. One has to marvel, whether or not the research authors actually imply to indicate {that a} complete of 13 boosters per yr are wanted (52 weeks/4 weeks = 13 boosters)? Or are they simply scripting this to get via peer assessment?
Additionally related is that “validated correlate of safety” is a exact regulatory time period. It signifies that in depth evaluation and characterization of each the precise take a look at used (neutralizing antibodies towards SARS-CoV-2), in addition to the connection between what it’s testing and the factor that it’s being developed to function a surrogate for (safety) has been carried out. Within the case of the present research, neither has occurred.
Due to this fact, no conclusions could be drawn from this research regarding what it’s measuring (presupposed to be neutralizing antibodies) and the endpoint for which it’s to function a surrogate for (safety) could be drawn. In different phrases, this paper is actually a preliminary research of no actual regulatory significance — it has not been carried out with the required rigor.
A extra unbiased conclusion primarily based on these knowledge is that the Pfizer/BioNTech BNT162b2 vaccine has exceptionally poor sturdiness of neutralizing antibody response (utilizing a non-validated or “educational analysis” degree take a look at) towards presently circulating viral strains.
In distinction, rising mRNA vaccine effectiveness knowledge from a number of nations are repeatedly demonstrating a dose dependent unfavourable effectiveness of those vaccines (in different phrases, the extra doses administered, the upper the chance of great COVID illness or demise).
The failure to handle these knowledge clearly demonstrates, as soon as once more, each the failure of the peer assessment course of, the irrational pro-vaccine bias of the authors, and the pro-vaccine bias of the editors of the Journal of the American Medical Affiliation.
When will goal, data-driven physicians and medical scientists ever have the ability to restore their prior religion within the Journal of the American Medical Affiliation, or will JAMA proceed to stay (for all sensible functions) only a pharmaceutical trade promotional commerce journal?
