Does Tirzepatide Work for Weight Loss?

Right here’s the evidence at New England Journal of Medicine for tirzepatide for weight loss. It’s a once-weekly injection. Value? Unknown to me.

At baseline, the imply physique weight was 104.8 kg, the imply BMI was 38.0, and 94.5% of members had a BMI of 30 or greater. The imply share change in weight at week 72 was −15.0% (95% confidence interval [CI], −15.9 to −14.2) with 5-mg weekly doses of tirzepatide, −19.5% (95% CI, −20.4 to −18.5) with 10-mg doses, and −20.9% (95% CI, −21.8 to −19.9) with 15-mg doses and −3.1% (95% CI, −4.3 to −1.9) with placebo (P<0.001 for all comparisons with placebo). The proportion of members who had weight discount of 5% or extra was 85% (95% CI, 82 to 89), 89% (95% CI, 86 to 92), and 91% (95% CI, 88 to 94) with 5 mg, 10 mg, and 15 mg of tirzepatide, respectively, and 35% (95% CI, 30 to 39) with placebo; 50% (95% CI, 46 to 54) and 57% (95% CI, 53 to 61) of members within the 10-mg and 15-mg teams had a discount in physique weight of 20% or extra, as in contrast with 3% (95% CI, 1 to five) within the placebo group (P<0.001 for all comparisons with placebo).

Three to 7% of customers stopped the drug as a result of unwanted effects.

Click for a Diabetes Daily article about the drug.

Steve Parker, M.D.

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